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KMID : 1103720100620050491
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Journal of the Korean Society of Radiology
2010 Volume.62 No. 5 p.491 ~ p.496
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Radio-Clinico-Pathologic Factors of False Negative 18F-FDG PET/CT Results in the Diagnosis of Breast Cancer
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Kim Do-Kyung
Choo Ki-Seok
Kim Seong-Jang
Bae Young-Tae
Lee Sang-Hyup
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Abstract
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Purpose: To identify radio-clinico-pathologic factors that result in false negative FDG uptake on 18F-FDG -PET/CT in the diagnosis of breast cancer.
Materials and Methods: We retrospectively reviewed a total of 140 breast lesions in 140 patients (mean age: 51.3 years) who underwent PET/CT for the staging of breast cancer from May 2007 to January 2008. All patients were divided as false negative (group 1, n=20) or true positive (group 2, n=120). A retrospective analysis was performed to analyze the statistical differences in clinico-pathologic factors between groups 1 and 2 using the Mann-Whitney U test, as well as the stepwise logistic regression analysis and the Chi-squared or Fisher’s exact test.
Results: Estrogen receptor positivity, mass on mammography, carcinoma in situ, and size were significantly different between groups 1 and 2 (p < 0.05). A stepwise logistic regression analysis showed that the estrogen receptor positivity (odds ratio, 5.623; 95% confidence interval: 1.100, 28.746; p = 0.021) and carcinoma in situ (odds ratio, 6.900; 95% confidence interval: 1.151, 41.361; p = 0.026) were significant clinico-pathology variables associated with false negative PET/CT findings.
Conclusion: Estrogen receptor positivity and carcinoma in situ may be helpful in the possible explanation of false negative PET/CT results in the diagnosis of breast cancer.
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KEYWORD
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18F-fluorodeoxyglucose Positron Emission Tomography, Breast, Neoplasms
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